Particle size reduction is a result of the particles impacting against the high speed rotor
The Alpine Hosokawa UPZ Fine impact mill in Pin Mill configuration is designed for the milling of API. The product is transferred by gravity from the feed screw outlet into the mill's inlet, where it is transported into the grinding chamber. Process gas is supplied to the grinding chamber via the product entry line, and particle size reduction is mainly a result of the particles impacting against the high-speed rotor.
The product fineness is influenced by the speed of the pin rotor and the amount of gas entering through the product line, which also functions to dissipate the generated heat. The ground product is pneumatically discharged from the mill, conveyed to the next filter, and collected in a container. The product feed rate and rotor speed control the final particle size distribution, with incoming air filtered through HEPA systems.
The Alpine Hosokawa UPZ Fine impact mill in Pin Mill configuration offers several advantages in API milling.
Its ability to handle a wide range of materials and achieve high product fineness with consistent particle size distribution is particularly noteworthy.
Using process gas in the milling process also allows for the dissipation of generated heat, preventing product degradation. Additionally, the mill's efficient design ensures minimal product loss and ease of cleaning, making it a reliable and cost-effective solution for API milling.
How it works
Pin mill technology
The Alpine Hosokawa UPZ Fine impact mill in Pin Mill configuration is designed for milling API. Its advantages include precise particle size control and efficient heat dissipation, with filtered incoming air for product purity.
- Particles impacting against the high speed rotor
- Particles break down through repeated impact
- The speed of the pin rotor influence the PSD
- > 50 microns
- UPZ technology
Benefits of Pin Mill Technology for API Milling
The advantages of Alpine Hosokawa UPZ Fine Impact Mill in Pin Mill Configuration for API Milling make it a reliable and cost-effective solution for API milling.
- Achieve tight PSD in a size range of 50 - 150 microns
- Harsh milling condition
Range of Application
- Pharmaceutical industry
- Oral dosage form
- Transdermal drug delivery
- Oncological solid dosage form
- New Chemical Entities, R & D